Marburgs variant of multiple sclerosis gouranga santra, avas chandra ray a 32 years female presented with sequential weakness of left half, followed by right half of body during last two and half months without any remission. Recent evidence suggests that humans get the virus through contact with infected animals. Marburg hemorrhagic fever marburg hf is a rare but severe hemorrhagic fever which affects both humans and nonhuman primates. Marburg virus marv is a highly pathogenic virus associated with. This is the key difference between ebola and marburg. Clinical aspects of marburg hemorrhagic fever ncbi nih. The marburg variant of multiple sclerosis, also known as acute, fulminant, or malignant multiple sclerosis, is characterized by extensive and fulminant acute demyelination, often resulting in death within one year after the onset of clinical signs please, refer on multiple sclerosis ms for a. Marburg virus has the potential to be a serious public health threat, yet much more research is needed for us to understand the pathogenesis of the disease. Primates including humans can become infected with marburg virus, and may develop serious disease with high mortality. Nihsupported experimental marburg vaccine prevents disease two days after infection an experimental vaccine developed to prevent outbreaks of marburg hemorrhagic fever continues to show promise in monkeys as an emergency treatment for accidental. Phylogenetic analysis created by using a neighborjoining. Marburg disease, the fulminant form of multiple sclerosis, is a rare disease that typically kills within a year.
While challenging, efforts to combine control of these diseases with other ntds, through mechanisms such as integrated surveillance and. Marburg hemorrhagic fever is a very rare human disease. Along with ebola virus, marburg virus causes a severe and highly fatal haemorrhagic fever called marburg virus disease which is. Last year, michelle barnes found out that she was the first american to have been diagnosed with a rare and deadly disease, known as marburg hemorrhagic fever. This naturally occurring virus can cause a fulminating hemorrhagic disease with a severe. As of 7 november, four cases of mvd have been reported two confirmed dead, one probable dead and one suspected. The virus causes the disease marburg hemorrhagic fever mhf, also referred to as marburg virus disease. Clinical aspects of marburg hemorrhagic fever medscape. Background an outbreak of marburg hemorrhagic fever was first observed in a goldmining village in northeastern democratic republic of the congo in october 1998.
Marburg virus disease definition of marburg virus disease. Marburg virus is considered to be a reemerging pathogen that poses a significant threat to human health. Marburg virus or simply marburg is the common name for the the genus of viruses marburgvirus, which contains one species, lake victoria marburgvirus. Combining all elements of the who recommended case definition epidemiological link plus at least 3.
A hitherto unknown infectious disease contracted from monkeys. Marburg hemorrhagic fever associated with multiple genetic. Mar 02, 2010 marburg disease, the fulminant form of multiple sclerosis, is a rare disease that typically kills within a year. Until now only single cases of diseases transmitted by monkeys are known as e.
Mice are incredibly easy to acquire and handle, and have by far the most. Forty years of marburg virus the journal of infectious. For marburg and ebola that element is the niemannpick c1 npc1 membrane protein 1. The above described constellation of findings are those brain demyelinating process with the right cerebellar hemisphere mass lesion conventional and spectroscopic criteria are very suggestive of tumefactive variant of multiple sclerosis marburgs variant of ms. Marburg virus marv is the causative agent of hemorrhagic fever outbreaks with high case fatality rates. Marburg hemorrhagic fever centers for disease control. Morphology, development, and classification of the marburg. Ebola is a retrovirus, having a negativestranded rna. Marburg and ebola viruses are both members of the filoviridae family filovirus.
Hcp may acquire infection from patients via contaminated clothes smallpox. Marburg virus disease previously known as marburg haemorrhagic fever is a virulent disease caused by the marburg virus and has a high case fatality rate cfr that can range between 2580%. Marburg virus pathogenesis differences and similarities in humans. The filoviruses ebola and marburg are zoonotic agents that are classified as both biosafety level 4 and category a list pathogens. Introduction marburg virus disease mvd formerly known as marburg hemorrhagic fever was first identified in 1967 during epidemics in marburg and frankfurt in germany and belgrade in the former yugoslavia from importation of infected monkeys from uganda. Marburg virus is a singlestranded rna virus genus marburgvirus, family filoviridae that is the etiologic agent of marburg hemorrhagic fever in humans and nonhuman primates mehedi et al. Because many of the signs and symptoms of marburg hemorrhagic fever are similar to those of other infectious diseases such as malaria or typhoid fever, clinical diagnosis of the disease can be difficult, especially if only a single case is involved.
Marburg virus definition is a filovirus species lake victoria marburgvirus of the genus marburgvirus that causes an often fatal hemorrhagic fever and was originally transmitted to. Online i can just fine a couple of news outlets with an article on it. It is not known exactly how humans become infected with the marburg virus. August 2016 importance ebolaviruses and marburgviruses are incompletely understood pathogens that. Marburg was not the only town whe re the virus was isolated and identified for the first time, but most cases of infection occurred in marburg. The marburg variant of multiple sclerosis, also known as acute, fulminant, or malignant multiple sclerosis, is characterized by extensive and fulminant acute demyelination, often resulting in death within one year after the onset of clinical sign. Rao md slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Comprehensive studies combining epidemiological data and ecological surveys will be. Marburg acute multiple sclerosis, also known as marburg multiple sclerosis or acute fulminant multiple sclerosis, is considered one of the multiple sclerosis borderline diseases, which is a collection of diseases classified by some as ms variants and by others as different diseases.
Marburg virus disease mvd formerly known as marburg haemorrhagic fever was first identified in 1967 during epidemics in marburg and frankfurt in germany and belgrade in the former yugoslavia from importation of infected monkeys from uganda. The 5 species of ebola are the other 5 members of the family. Marburg virus is a singlestranded rna virus genus marburgvirus, family. The first outbreak occurred simultaneously in 1967 in marburg, frankfurt, and belgrade with 31 human cases, 7 of which were. Marburg virus marv causes marburg virus disease in humans and nonhuman primates, a form of viral hemorrhagic fever. It typically has many of the same symptoms of multiple sclerosis, and treatment tends. Viral hemorrhagic fevers, filovirus, diseases contagious from animals. Marburg virus disease uganda, 25 october 2017 uganda. Marburg is a virus that is in the same family as ebola, and it basically has very similar characteristics, said dr.
The marburg variant of multiple sclerosis, also known as acute, fulminant, or malignant multiple sclerosis, is characterized by extensive and fulminant acute demyelination, often resulting in death within one year after the onset of clinical signs. Ebola and marburg virus disease epidemics world health. Ebola virus causes the ebola viral disease, whereas marburg virus causes the marburg viral disease. Marburg hemorrhagic fever associated with multiple genetic lineages of virus. Pdf studies of reservoir hosts for marburg virus researchgate. Marburg haemorrhagic fever was initially detected in 1967 after simultaneous outbreaks in marburg and frankfurt in germany. Marburg virus singapore pdf ppt case reports symptoms. The transmission of the marburg agent from monkey to man was governed by the occurrence of high infectivity in blood and organs of the animals 1, 2. Marburg virus is one of 2 viruses belonging to the filovirus family.
Marburg virus disease is caused by viruses that produce symptoms of fever, chills, headaches and muscle aches early in the disease. Once a person is infected, the virus can spread through persontoperson contact. In the late summer of 1967, several patients suffering from a severe disease were admitted to the department of medicine of the marburg university. The marburg virus is a genetically unique zoonotic that is, animalborne rna virus of the filovirus family, and its recognition led to the creation of this virus family. However, when it does occur, it has the potential to spread to other people, especially health care staff and family members who care for the patient. Marburg virus definition is a filovirus species lake victoria marburgvirus of the genus marburgvirus that causes an often fatal hemorrhagic fever and was originally transmitted to humans from green monkeys. Marburg hf is caused by marburg virus, a genetically unique zoonotic or, animalborne rna virus of the filovirus family. Marburg virus news and research rss marburg virus or simply marburg is the common name for the the genus of viruses marburgvirus, which contains one species, lake victoria marburgvirus. The incubation period for marburg disease is 221 days in humans and 420 days in. Outbreak of a new disease in early august 1967, patients with unusual symptoms indicating an infectious disease were admitted to the university hospitals in marburg and frankfurt. The diagnosis of marburg disease is coursedependent. Fruit bats infected with marburg virus do not to show obvious signs of illness.
The patient recovered clinically after surgery and stayed stable for more than a year. Marburg virus is a hemorrhagic fever virus of the filoviridae family of viruses and a member of the species marburg marburgvirus, genus marburgvirus. Amesh adalja, a spokesman for the infectious disease society of america. First seen among laboratory workers in marburg, germany. Marburg disease definition, a viral disease producing a severe and often fatal illness with fever, rash, diarrhea, vomiting, and gastrointestinal bleeding, transmitted to humans through contact with infected green monkeys. Aug 23, 2018 marburg virus is considered to be a reemerging pathogen that poses a significant threat to human health.
Risk factors include exposure to african green monkeys and certain bats. Transactions of the royal society of tropical medicine and hygiene. It soon became obvious that the illness was a hitherto unknown infectious disease. This free and easy to use online tool allows to combine multiple pdf or images files into a single pdf document without having to install any software. Results matching topic of marburg virus page 1 of 1. Marburg variant of multiple sclerosis radiology reference. Marburg multiple sclerosis is a subtype of ms with only one lesion may be present. Marburg originated in central and east africa, and infects both human and nonhuman primates. Examples of marburg or ebola virus disease case definitions that may be used. Select up to 20 pdf files and images from your computer or drag them to the drop area.
Once the marburg virion attaches, the virion envelop fuses with the cellar membrane and then the nucleocapsid is released into the cytosol. First outbreak, 1967, in marburg and frankfurt germany due to research on african green monkeys. There are four different main types of multiple sclerosis, but there are many other diseases and subtypes that fall into the ms category. Oct 31, 2017 marburg is a virus that is in the same family as ebola, and it basically has very similar characteristics, said dr. Marburg haemorrhagic fever who regional office for africa. This protein mediates infection by binding to the viral envelope. Marburg hemorrhagic fever centers for disease control and. Why is there no wikipedia entry for the marburg files. The disease, characterized by a prominent rash and hemorrhages in many organs, is often fatal. Marburg haemorrhagic fever was initially detected in 1967 after simultaneous outbreaks in marburg, from which the disease takes its name, and frankfurt in germany.
Life cycle mode of infection and transmission home. Just watched the episode related to this and tried to research a bit more info. Deadly marburg virus outbreak declared in uganda cnn. We had a 38yearold african american male who presented with right footdrop and was pathologically diagnosed with marburg disease. Ebola virus and marburg virus disease reference guide. One species has been described, marburg marburgvirus formerly lake victoria marburgvirus, which is represented by two viruses, ravn virus ravv and marburg virus marv. Rather high titers were also observed in infected guinea pigs 3, 4, 5. Early diagnosis and aggressive management is vital to. Ebola belongs to the virus family called filoviridae. Marburg haemorrhagic fever was initially detected in 1967 after simultaneous outbreaks in marburg, from which the disease takes its name. On 17 october 2017, the ugandan ministry of health notified who of a confirmed outbreak of marburg virus disease in kween district, eastern uganda. The virus that causes marburg hemorrhagic fever, a disease which affects both humans and nonhuman primates. In fact, marburg multiple sclerosis can be considered a multiple sclerosis borderline disease, meaning some medical professionals consider it a subtype of ms and others may consider it as a completely different disease. Marburg virus disease mvd, formerly known as marburg haemorrhagic fever, is a severe, often fatal illness in humans.
It was discovered in 1967 in an epidemic in marburg, germany, and serbia, following exposure to african green monkeys, with 32 cases and seven deaths among laboratory workers and their families and caregivers. O group 2 infection from monkeykidney cell cultures. This protein mediates infection by binding to the viral envelope glycoprotein. Marburg hemorrhagic fever mhf was first described in 1967 in an outbreak in germany and the. For the marburg virus to infect the hosts cell an essential element is needed. Why does marburg not even show up in edwards wikipedia. Mvd is a viral hemorrhagic fever vhf, and the clinical symptoms are indistinguishable from ebola virus disease evd. Get the facts on the history, symptoms, and treatment of marburg virus disease, formerly known as marburg hemorrhagic fever.
The casefatality rate for marburg hemorrhagic fever is between 2390%. Marburgvirus infections ebola and marburg virus disease, ebola and marburg hemorrhagic fever, african hemorrhagic fever in africa. Marburg variant of multiple sclerosis ms is a highly aggressive, fulminant demyelinating disease with very high morbidity and mortality. Marburg virus brazil pdf ppt case reports symptoms. Marburg disease definition of marburg disease by medical. Nihsupported experimental marburg vaccine prevents. After the initial transmission, the viruses can spread from person to person through contact with body fluids or contaminated needles. The new disease observed in marburg, frankfurt, and belgrade was the first to occur in an epidemic outbreak. Mapping the zoonotic niche of marburg virus disease in africa. In this table, provisional cases of notifiable diseases are displayed for united states, u. Closely related to ebola virus, marv is a filamentous virus with a negativesense, single. Marburg virus definition of marburg virus by merriamwebster.
Marburg virus is related to the ebola virus in that both viruses belong to the filovirus family. We had a 38yearold african american male who presented with right footdrop and. Marburgvirus, genus of viruses in family filoviridae, known for causing severe disease in humans and other primates. The reservoir host of marburg virus is the african fruit bat, rousettus aegyptiacus. Marburg disease also termed malignant ms is a rare, acute ms variant that. Viral hemorrhagic fevers, machupo virus to viral hemorrhagic fevers, sabia virus 2019. These viruses are pathogenic in humans and cause isolated infections or epidemics of viral hemorrhagic fever, mainly in central africa.
Marburg disease, marburg hemorrhagic fever, marburg. Marburg virus disease an overview sciencedirect topics. Accumulation of filoviral mature virions develops when the preformed nucleocapsids acquire envelopes by passing through the host cell. If you continue browsing the site, you agree to the use of cookies on this website.
The causal agent of marburg hemorrhagic fever is a virus of the filoviridae family, which also includes the ebola virus. Marburg virus is the causative agent of marburg virus disease mvd, a disease with a case fatality ratio of up to 88%. Results matching topic of marburg virus page 1 of 1 data. Other diseases in this group are neuromyelitis optica nmo, balo concentric sclerosis, and schilders disease.